RESEARCH PROFILE

I want to understand the mechanochemical processes underlying directional cell migration and polarity. We focus on the mechanisms that generate specific microtubule arrays and study the dynamic interactions of microtubules with the cell cortex during cell shape changes and spindle positioning. We are using live-cell imaging and biochemical approaches paired with RNA interference and target protein mutagenesis to analyse structure-function relationships of motor proteins, structural MAPs and the +TIP complex.

CURRENT RESEARCH PROJECTS

• RDF 12/13 QMUL AWARD: Nanoscale localisation of microtubule plus end binding proteins using multispectral super-resolution imaging, Funded by: Research Development Fund, Project Start Date: 01/12/2012 Project End Date: 31/07/2013
  
  

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SELECTED PUBLICATIONS

• Hawkins, T.L., Sept, D., Mogessie, B., Straube, A. and Ross, J.L. (2013) 'Mechanical Properties of Doubly-Stabilized Microtubule Filaments' Biophysical Journal 104 1517 - 1528
• Theisen, U., Straube, E. and Straube, A. (2012) 'Directional Persistence of Migrating Cells Requires Kif1C-Mediated Stabilization of Trailing Adhesions' Developmental Cell 23 (6), 1153 - 1166
• McAinsh, A.D. and Straube, A. (2011) 'Spindle centricity' Cell Cycle 10 (23), 3989 - 3991
• Kaverina I, Straube A (2011) 'Regulation of cell migration by dynamic microtubles' Seminars In Cell And Developmental Biology
• Cross RA, McAinsh AD, Straube A. (2011) 'Mechanochemical cell biology' Seminars In Cell And Developmental Biology

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Conferences

RESEARCH DEGREES SUPERVISED

• Cellular functions of MAP4 in mitosis and muscle differentiation, Date of Completion: 2011
• Regulation of microtubule assembly by mammalian EB proteins.
• Modelling and regulation of cell shape fluctuations